the influence of human leukocyte antigen and il-10 gene polymorphisms on hepatitis b virus outcome
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The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome
CONTEXT The clinical outcome of hepatitis B virus (HBV) infection is variable, ranging from spontaneous recovery to an inactive carrier state, chronic hepatitis, occult HBV infection, liver cirrhosis, or hepatocellular carcinoma. EVIDENCE ACQUISITION This variable pattern and clinical outcomes of the infection were mainly determined by virological and host genetic factors. Since the most of h...
متن کاملAssociation of IL-10 polymorphisms with hepatitis B virus infection and outcome in Han population
BACKGROUND This study evaluated the correlation of single nucleotide polymorphisms interleukin (IL)-10-592 and -1082 with hepatitis B virus (HBV) susceptibility and recovery. METHODS Total 190 chronic hepatitis B (CHB) patients, 81 individuals with self-limited HBV infections and 81 normal controls from the first Hospital of Jilin University were recruited. The IL-10 polymorphisms were detect...
متن کاملno correlation between interleukin-10 gene promoter polymorphisms and hepatitis b virus infection outcome
objectives this study evaluates the correlation between hbv infection and snp in il-10 gene promoter. patients and methods ninety-six hbv-infected patients (32 chronic hepatitis b infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. three biallelic (-819,-592,-1082) regions in the il-10 gene promoter were sequenced for all patients. r...
متن کاملimpact of the il-10 promoter gene polymorphisms in the severity of chronic hepatitis b infection
conclusions some il-10 promoter gene polymorphisms predisposed the infected hepatitis b virus cases to cirrhosis in our study population. patients and methods totally, 166 patients with chronic hepatitis b infection were enrolled. genotypes at different positions (i.e. -819, - 592, and - 1082) in the il-10 gene promoter were determined. results the c/a genotype at position -592, c/t genotype at...
متن کاملNo Correlation Between Interleukin-10 Gene Promoter Polymorphisms and Hepatitis B Virus Infection Outcome
BACKGROUND Single nucleotide polymorphisms (SNP) in the promoter region of the interleukin (IL)-10 genes have a role in determining hepatitis B virus (HBV) outcome. OBJECTIVES This study evaluates the correlation between HBV infection and SNP in IL-10 gene promoter. PATIENTS AND METHODS Ninety-six HBV-infected patients (32 chronic hepatitis B infection patients, 34 healthy carriers, 30 spon...
متن کاملThe interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma Short title: IL-10 polymorphisms and lymphoma outcome
(4217 articles) Neoplasia (4939 articles) Immunobiology (3667 articles) Clinical Trials and Observations Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylib...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۲، شماره ۵، صفحات ۳۲۰-۳۲۵
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